February 19, Wed 2013
3:30 pm, 1005 Haworth
Dr. Joanna Slusky
Fox Chase Cancer Center, Institute for Cancer Research
The Ins and Outs of Charge in Membrane Proteins
Membrane proteins comprise 30% of all proteins and are the majority of modern drug targets. My talk will span both the inner and outer membrane and will use methodologies ranging from molecular biology to protein design to bioinformatics. I will discuss I) how charge affects membrane protein insertion and topology in the inner membrane, II) the relative forces responsible for membrane protein-protein interactions, and III) how charge location clarifies a mechanism for protein insertion in the outer membrane.